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Study: Green tea, dark chocolate may fight against COVID-19 virus
"Mpro in SARS-CoV-2 is required for the virus to replicate and assemble itself. If we can inhibit or deactivate this protease, the virus will die," Xie said. Computer simulations showed that the studied chemical compounds from green tea, two varieties of muscadine grapes, cacao powder, and dark chocolate were able to bind to different portions of Mpro.
"Mpro has a portion that is like a 'pocket' that was 'filled' by the chemical compounds. When this pocket was filled, the protease lost its important function," Xie explained. Lab experiments also showed similar results. The chemical compounds in green tea and muscadine grapes were very successful at inhibiting Mpro's function; chemical compounds in cacao powder and dark chocolate reduced Mpro activity by about half.
"Green tea has five tested chemical compounds that bind to different sites in the pocket on Mpro, essentially overwhelming it to inhibit its function," Xie said. "Muscadine grapes contain these inhibitory chemicals in their skins and seeds. Plants use these compounds to protect themselves, so it is not surprising that plant leaves and skins contain these beneficial compounds," the author noted.
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