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Study: Fasting for 18 hrs a day could help slow down ageing and fight cancer
The three most-widely studied intermittent fasting regimens are alternate-day fasting, 5:2 intermittent fasting (fasting two days each week), and daily time-restricted feeding (eat during specific hours of the day). When food is restricted to 500 to 700 calories one or more days every week, the level of ketones in the body rises.
"Periodic flipping of the metabolic switch not only provides ketones that are necessary to fuel cells during the fasting period but also elicits highly orchestrated systemic and cellular responses...to bolster mental and physical performance, as well as disease resistance," the study says.
Earlier studies have also demonstrated similar findings. For instance, a study by Weindruch and Sohal, published in the NEJM in 1997, found that reducing food availability over a lifetime (caloric restriction) slows aging in animals. The new study, however, also cautions that switching to an intermittent fasting regimen may make people irritable and they may experience a reduced ability to concentrate during periods of food restriction. "These initial side effects usually disappear within one month....," it notes.
The review also says it remains to be determined whether people can go on intermittent fasting for years to "potentially accrue the benefits seen in animal models". Also, clinical studies conducted till now have focused mainly on overweight young and middle-aged adults. "We cannot generalise to other age groups the benefits and safety of intermittent fasting that have been observed in these studies," the research notes.
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